Anemia of Chronic Kidney Disease Market Report gives readers a thorough assessment of key market drivers, restraints, prospects, opportunities, restraints, current trends, and technological and industrial breakthroughs that will influence market growth. The detailed market research, industry sector growth and development, and new product introductions covered in this report on the Anemia of Chronic Kidney Disease Market are of great assistance to the important new commercial players joining the market.
This Anemia of Chronic Kidney Disease Market report research conducts a careful market evaluation and provides a professional analysis of the industry taking into account market development, present market circumstances, and forecasts for the future. The market driving factors, market overview, industry volume, and market share are also highlighted in this Anemia of Chronic Kidney Disease Market report analysis.
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Anemia of Chronic Kidney Disease: An Overview
Anemia is a frequent complication of chronic kidney disease (CKD) and is associated with a decrease in the quality of life of patients causing an increase in morbidity and mortality. It is also believed to accelerate the rate of progression of CKD. Anemia in chronic kidney disease is typically attributed to the decrease of erythropoietin production that accompanies the fall in Glomerular filtration rate (GFR).
Key highlights of the Anemia of Chronic Kidney Disease Market Report
Anemia of Chronic Kidney Disease Epidemiology Insights
Anemia in chronic renal disease is a multifactorial condition, the widely accepted etiology being decreased renal production of erythropoietin, the hormone that is responsible for the stimulation of red blood cells production. Decreased erythropoietin has recently linked with down regulation of hypoxia-inducible factor (HIF), a transcription factor that regulates gene expression of erythropoietin. Other mechanisms include uremia (leading to RBC deformity responsible for hemolysis), folate and vitamin B12 deficiency, iron deficiency, bleeding due to dysfunctional platelets, and rarely blood loss from hemodialysis.
Anemia of Chronic Kidney Disease Epidemiology Segmentation in the 7MM
Anemia of Chronic Kidney Disease Treatment Market
Currently, the treatment paradigm for Anemia in Chronic Kidney Disease involves use of Iron therapies, Erythropoietin stimulating agent (ESA) therapies, Red Blood Transfusions, Vitamin B12 & Folic Acid Supplements and nutrition. ESAs and iron therapies are the most potent and commonly followed treatment procedures for anemia associated with Chronic Kidney Disease. ESAs are used to stimulate erythropoiesis by either directly or indirectly acting on the erythropoietin receptor. There are two types of ESA therapies available in the United States, Europe and Canada named as Epogen (Epoetin Alfa) and Aranesp (Darbepoetin Alfa) for the treating anemia associated due to chronic kidney disease.
Anemia of Chronic Kidney Disease Market Insights
According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Anemia commonly occurs in people with chronic kidney disease (CKD) which results into permanent, partial loss of kidney function. Anemia might begin to develop in the early stages of CKD, when someone has 20 to 50 percent of normal kidney function. Anemia tends to worsen as CKD progresses. Most people who have total loss of kidney function, or kidney failure, have anemia.
Anemia of Chronic Kidney Disease Market Forecast
The development of recombinant EPO followed by erythropoiesis-stimulating agents (ESAs) revolutionized the management of anemia in CKD. Although initially instituted to avoid transfusions, they were soon known to have various positive effects, including improved survival and quality of life, improved cardiac function and mortality associated with it, lower hospitalizations,and lower costs. Recombinant human erythropoietin and darbepoetin alfa are the two ESAs generally used in the management of anemia in CKD. They are fairly similar in efficacy and side effect profile, except for the longer half-life of darbepoetin alfa, thus allowing for less frequent dosing.
Anemia of Chronic Kidney Disease Market Size
The market size shall grow during the forecast period owing to the launch of upcoming therapies. The market size is expected to increase at a CAGR of XX during the study period. Expected launch of Vadadustat, Daprodustat shall fuel the growth of the market during the forecast period, i.e., 2020–2030.
Anemia of Chronic Kidney Disease Market Dynamics
Traditional molecules for intravenous administration may cause rare but fatal anaphylactic reactions (especially for high molecular weight iron dextran), severe hypotension due to ‘labile’ iron (iron sucrose or iron gluconate) or need to be given at repeated small doses with a long infusion time in order to avoid toxicity (iron gluconate and iron sucrose). In order to avoid this several key players such as Akebia Therapeutics, GlaxoSmithKline, Astellas Pharma, FibroGen, Inc and many others are working on developing therapies for treatment of Anemia in Chronic Kidney Disease.
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